IRB Procedures

Important Note
Please be sure to renew your CITI training every 3 years before submitting an IRB proposal.
CITI Research Ethics and Compliance Training

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Here is some information from TSG on this:  Please use the Firefox ESR version we have available in the Software Center. The public version is not a stable release and updates so often it leaves security gaps. To get to the Software Center, simply click on your start button and scroll down to the folder Microsoft System Center and click the link in that folder. You will find Firefox ESR. As part of requesting Firefox ESR, we need a short statement about usage (that’s part of the request process).  This will allow us to track how many users are using the software as well as for what purpose.  That will allow for future opportunities in our Software Center.  Firefox is the preferred browser for Cayuse only.  Internet Explorer (IE) is the preferred browser for EIS. 

Background Information

Cayuse IRB is a system used for electronically preparing, submitting, and routing studies for IRB approval. All information is stored in the cloud and can be accessed securely from any location, making it simple for multiple simultaneous users to view and share documents. Users receive electronic notifications whenever an action is required on their part, allowing the study to proceed through each step of the process from study creation to final approval.


All pending or approved studies submitted prior to March 1st will be processed using the current procedures (i.e. emailing Word documents). All studies submitted on or after March 1st must be submitted through the new Cayuse IRB system. Any new studies submitted using the prior procedures will not be accepted.

Legacy Data

All pending or approved studies submitted prior to March 1st will not be in the new system. Adding existing pending/approved studies to the system will require closing the study and resubmitting it. Transferring legacy data into the system would have  increased administrative burden on researchers and staff.


If you have submitted proposals via Cayuse 424, no action is required; you will see the Cayuse IRB option listed when you log into using single sign on. If you have not submitted proposals via Cayuse 424 and you do not see the Cayuse IRB option, you will need to submit a request to gain access to the system via this link: Please note, the turnaround time to gain access can take up to 72 hours.

Submission Processing Timeframe

We do not anticipate any changes to our current turnaround time for processing submissions.

Communication Regarding Submissions

Any and all communication (i.e. actions taken, review memos, approval letters) related to your protocols will be handled in the system. You will receive notifications from Cayuse to your email. You will no longer have to email for status updates or questions regarding your submission.


We have a step-by-step submission guide available on our website to walk you through the process of submitting a protocol. We also have a quick step guide that offers more concise instructions. If you would like to schedule an in-person training session with a member of our office for yourself or a group of individuals, please contact Jillian Byrne-Sweeney to schedule at

Contact Information

If you have questions or issues related to the content as you are submitting your protocol in the system, please email us at or call 940-565-4643. If you have software or technical issues while completing your protocol in the system, please contact

We are here to help you as we make this transition, so please do not hesitate to contact us with any questions or concerns.

UNT IRB Email:

UNT IRB Main Phone Number: 940-565-4643

Office of Research Integrity and Compliance Contact Information:

Jamie Peno, Director:

Janice Magrini, Sr. Research Analyst:

Jillian Byrne-Sweeney, Research Analyst:

Research Integrity Compliance