Recent advancements in generative artificial intelligence (AI), especially large language models (LLMs), have added a new dimension to the capabilities of NPCs (non-player characters) within these environments. These AI agents, powered by models like GPT, enable natural language understanding and generation, which allows users to engage in real-time, emotionally intelligent conversations. The goal of research in Virtual AI Health Assistants is to develop intelligent systems that can support, enhance, or automate healthcare services through natural and effective interaction with patients and healthcare providers. These assistants aim to provide accessible, personalized, and efficient care using artificial intelligence. Our vision is to create AI-powered assistants that are safe, reliable, empathetic, and medically competent, serving as partners in health management for both patients and professionals. Embedded within this environment are ConvAI-powered GPT NPCs that serve as the primary interface for user interaction. These agents engage in real-time conversations with users, helping them reflect on their emotional state, explore cognitive-behavioral techniques, and participate in mindfulness activities. The NPCs are capable of mood detection, enabling them to adapt their responses based on the user’s current affective state. This makes the interactions more authentic and supportive, mimicking the empathy and attentiveness of human therapists. Our objectives are
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